HCID 58903181, compound → HCID 57413290, compound

Participants

Reaction Steps

Methyl 3-[4-[[4′-(2-ethoxyethoxy)-2′,6′-dimethylbiphenyl-3-yl]methoxy]phenyl]propanoate (0.12 g, 0.26 mmol) was dissolved in a mixed solution of methanol (2 mL) and tetrahydrofuran (4 mL), and 1 N aqueous sodium hydroxide solution (0.52 mL) was added at room temperature with stirring. The mixture was stirred at the same temperature for 2 hrs. After the completion of the reaction, the reaction mixture was diluted with ethyl acetate, washed successively with 1 N hydrochloric acid, water and saturated brine, dried and concentrated under reduced pressure. The residue was crystallized from hexane/ethyl acetate=4/1 to give the title compound (0.087 g, yield 75%) as colorless crystals.

Provenance & Evidence