Acetic Acid → 3-[4-({4'-[2-(Ethylsulfonyl)ethoxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2-fluorophenyl]propanoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 3-[4-({4′-[2-(ethylsulfonyl)ethoxy]-2′,6′-dimethylbiphenyl-3-yl}methoxy)-2-fluorophenyl]propanoate (0.19 g, 0.35 mmol), acetic acid (4.5 mL), water (4.0 mL) and conc. sulfuric acid (0.65 mL) was stirred at 90° C. for 4 hrs. The reaction mixture was cooled, diluted with ethyl acetate, washed with water and saturated brine, dried and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1-ethyl acetate) to give the title compound (0.12 g, yield 61%) as colorless crystals.

Provenance & Evidence