反应详情

Perindopril benzyl ester (1.4 g) obtained in Step VI was dissolved in absolute ethanol (15 ml). To the solution was added 10% Pd—C (5% w/w) and the mixture hydrogenated at 20-22° C. for 3 hours till completion of the reaction. The catalyst was filtered off and the filtrate concentrated under reduced pressure at 45° C. to give 1.3 g of perindopril (II).

1. customthe mixture hydrogenated at 20-22° C. for 3 hours till completion of the reaction
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate concentrated under reduced pressure at 45° C.