反应详情

The Perindopril benzyl ester (2.9 g, 6.33 mmoles) dissolved in ethyl alcohol (15 ml) hydrogenated using 10% Palladium on carbon (0.29 g), under 45-50 psi hydrogen pressure for 2.5-3 hrs. The reaction was performed at 25-30° C. After completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated under reduced pressure to afford Perindopril as a viscous oil.

1. customwas performed at 25-30° C
2. customAfter completion of the reaction
3. filtrationthe reaction mixture was filtered
4. customto remove the catalyst
5. concentrationthe filtrate was concentrated under reduced pressure