HCID 59837649, compound → HCID 11649873, compound

HRID 273539Notes

Reaction equation

BrC1C=CC(S(N(C)CCN2CCOCC2)(=O)=O)=CC=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([O:28]C)=[CH:24][C:23]=1[C:30]1[CH:59]=[C:58]([CH3:60])[C:33]2[N:34]=[C:35]([NH:38][C:39]3[CH:44]=[CH:43][C:42]([S:45]([N:48]([CH3:57])[CH2:49][CH2:50][N:51]4[CH2:56][CH2:55][O:54][CH2:53][CH2:52]4)(=[O:47])=[O:46])=[CH:41][CH:40]=3)[N:36]=[N:37][C:32]=2[CH:31]=1>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][C:23]=1[C:30]1[CH:59]=[C:58]([CH3:60])[C:33]2[N:34]=[C:35]([NH:38][C:39]3[CH:40]=[CH:41][C:42]([S:45]([N:48]([CH3:57])[CH2:49][CH2:50][N:51]4[CH2:56][CH2:55][O:54][CH2:53][CH2:52]4)(=[O:46])=[O:47])=[CH:43][CH:44]=3)[N:36]=[N:37][C:32]=2[CH:31]=1

Participants

Reactant 2

HCID 59837649HCID 59837649, compound

HCID 59837772HCID 59837772, compound

Product 1

HCID 11649873HCID 11649873, compound

Procedure

To synthesize the title compound (CLXXII), intermediate compounds 67 (4-bromo-N-methyl-benzenesulfonamide), 68 (4-bromo-N-methyl-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide) and 69 (4-[7-(2-chloro-5-methoxy-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamino]-N-methyl-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide) shown below were used.

Sources & evidence

ORD record: ord-52c94122757d41809532d2e815d4a706
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07456176B2

Reaction notes

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