Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273544Generated: October 26, 2026

Methyl iodide → 5-(4-chlorophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

https://huagongshe.com/reaction/273544

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
Reactantt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—
ReagentSulfuric AcidHCID 1118—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
Product5-(4-chlorophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamideHCID 7068958351%
Productt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-5354d26f14f84abdbb1a215752e50b91
Source noteCernak miniaturized N-alkylation with BOC deprotection