Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273547Generated: October 30, 2026

Methyl iodide → 5-(4-chlorophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

https://huagongshe.com/reaction/273547

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
Reactantt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—
ReagentSulfuric AcidHCID 1118—
ReagentHCID 178418261HCID 178418261—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
Product5-(4-chlorophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamideHCID 7068958355%
Productt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-e262abaa7180491c9caa034a3b6290c1
Source noteCernak miniaturized N-alkylation with BOC deprotection