HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273557Generated: October 26, 2026
Butyl iodide → N-butyl-5-(4-chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide
https://huagongshe.com/reaction/273557
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Butyl iodide | HCID 10962 | — |
| Reactant | t-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate | HCID 168301698 | — |
| Reagent | Sulfuric Acid | HCID 1118 | — |
| Reagent | tert-Butylimino-tri(pyrrolidino)phosphorane | HCID 3856267 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | N-butyl-5-(4-chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide | HCID 70691713 | 80% |
| Product | t-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate | HCID 168301698 | — |
Provenance & Evidence
| DOI | 10.1038/s44160-023-00351-1 |
|---|
| Source dataset | Cernak miniaturized N-alkylation with BOC deprotection |
|---|
| ORD ID | ord-c90772906fa74908aa9347a201a26c34 |
|---|
| Source note | Cernak miniaturized N-alkylation with BOC deprotection |
|---|
