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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273566Generated: October 26, 2026

2-(Bromomethyl)pyridine → 5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide

https://huagongshe.com/reaction/273566

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Bromomethyl)pyridineHCID 564209—
Reactantt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—
ReagentSulfuric AcidHCID 1118—
ReagentSodium t-butoxideHCID 23676156—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
Product5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamideHCID 53475321106%
Productt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-3a859294be5d4621ad4f5e26a7a8d3f9
Source noteCernak miniaturized N-alkylation with BOC deprotection