Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273582Generated: November 1, 2026

1,1'-Biphenyl, 4-(bromomethyl)- → N-([1,1'-biphenyl]-4-ylmethyl)-5-(4-chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

https://huagongshe.com/reaction/273582

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-Biphenyl, 4-(bromomethyl)-HCID 257716—
Reactantt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—
ReagentSulfuric AcidHCID 1118—
ReagentSodium t-butoxideHCID 23676156—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
Productt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—
ProductN-([1,1'-biphenyl]-4-ylmethyl)-5-(4-chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamideHCID 16830170266%

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-3de729359613425fbbd335ac77f30c90
Source noteCernak miniaturized N-alkylation with BOC deprotection