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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273594Generated: October 31, 2026

Methyl iodide → 5-(4-cyanophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

https://huagongshe.com/reaction/273594

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
ReactantTert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301699—
ReagentSulfuric AcidHCID 1118—
ReagentSodium t-butoxideHCID 23676156—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
ProductTert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301699—
Product5-(4-cyanophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamideHCID 16830171042%

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-2edb269897674bc0bbc12789b287a7d5
Source noteCernak miniaturized N-alkylation with BOC deprotection