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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273596Generated: October 30, 2026

Iodoethane → 5-(4-cyanophenyl)-N-ethyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

https://huagongshe.com/reaction/273596

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoethaneHCID 6340—
ReactantTert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301699—
ReagentSulfuric AcidHCID 1118—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
ProductTert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301699—
Product5-(4-cyanophenyl)-N-ethyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamideHCID 16830171145%

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-6ea267a6801c4e27909aa635e32aefc6
Source noteCernak miniaturized N-alkylation with BOC deprotection