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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273629Generated: October 29, 2026

1,1'-Biphenyl, 4-(bromomethyl)- → HCID 57401827, compound

https://huagongshe.com/reaction/273629

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-Biphenyl, 4-(bromomethyl)-HCID 257716—
ReactantTert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301699—
ReagentSulfuric AcidHCID 1118—
Reagenttert-Butylimino-tri(pyrrolidino)phosphoraneHCID 3856267—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
ProductHCID 57401827HCID 5740182786%
ProductTert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301699—

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-339370fa29e04209a79fb70132faece0
Source noteCernak miniaturized N-alkylation with BOC deprotection