反应详情

A mixture of 2-[2(R/S)-hydroxy-2-(2-methoxy-5-ethyl-6-methylpyridin-3-yl)ethyl]benzoxazole (72 mg, 0.23 mmol) and pyridine hydrochloride (133 mg, 1.2 mmol), under a nitrogen atmosphere, was placed in a preheated oil bath (165° C.) for 5 minutes. The reaction flask was removed, cooled, and water added to give a solid. This crude product was extracted into chloroform, dried (MgSO4) and the solvent evaporated to yield 49 mg (75%) of pure product. Recrystallization from methanol gave 15 mg of analytically pure product, mp 262°-264° C.

1. customunder a nitrogen atmosphere, was placed in a preheated oil bath
2. customThe reaction flask was removed
3. temperaturecooled
4. additionwater added
5. customto give a solid
6. extractionThis crude product was extracted into chloroform
7. dry with materialdried (MgSO4)
8. customthe solvent evaporated