HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[2-(benzoxazol-2-yl)ethenyl]-5-ethyl-6-methyl-2-(1H)-pyridinone → 2-Methoxy-5-ethyl-6-methylnicotinaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[2-(benzoxazol-2-yl)ethenyl]-5-ethyl-6-methyl-2-(1H)-pyridinone | HCID 454826 | — |
| Reactant | Ethanol tetrahydrofuran methanol | HCID 66624091 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 2-Methoxy-5-ethyl-6-methylnicotinaldehyde | HCID 10261679 | — |
Reaction Steps
A solution of 80% pure 3-[2-(benzoxazol-2-yl)ethenyl]-5-ethyl-6-methyl-2-(1H)-pyridinone (200 mg) in methanol/ethanol/THF (25 mL, 1:1:1) was hydrogenated at atmospheric pressure over 5% palladium/charcoal for four hours. After filtering off the catalyst, the solvents were evaporated and the residue flash chromatographed over silica gel. Elution with 2% methanol-98% chloroform gave 75 mg of analytically pure product, mp 155°-156.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05387512 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-f3f571178e3943a78a64a0d0a61bae24 |
| Source note | uspto-grants-1995_02 |