Androsta-4,6-diene-3,17-dione → HCID 23383196, compound

HRID 273695Notes

Reaction equation

HRID 273695 reaction equation
[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C@@H:7]([CH:8]=[CH:9][C:10]4[C@:15]3([CH3:16])[CH2:14][CH2:13][C:12](=[O:20])[CH:11]=4)[C@@H:6]1[CH2:5][CH2:4][C:3]2=[O:21].[CH3:22][Mg]Br>>[CH3:22][C@@H:8]1[CH2:9][C:10]2[C@:15]([CH3:16])([CH2:14][CH2:13][C:12](=[O:20])[CH:11]=2)[C@@H:17]2[C@@H:7]1[C@H:6]1[C@@:2]([CH2:19][CH2:18]2)([CH3:1])[C:3](=[O:21])[CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 12452Androsta-4,6-diene-3,17-dioneHCID 178418573HCID 178418573, compound

Product 1

HCID 23383196HCID 23383196, compound

Procedure

androsta-4,6-dien-3,17-dione 17 ketal (XXXVIII) is reacted with methyl magnesium bromide in the presence of cuprous chloride to produce 7α-methylandrost-4-ene-3,17-dione 17 ketal (XXXIX)

Sources & evidence

ORD record
ord-38f68285bcab460e9136f8ed320f7007
Source dataset
uspto-grants-1995_02
Patent number
US05387583

Reaction notes

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