5-Androstene-3 beta,7 beta,17 beta-triol → Androstane-3,7,17-triol, (3beta,5alpha,7beta,17beta)-

HRID 273696Notes

Reaction equation

HRID 273696 reaction equation
[OH:1][C@H:2]1[CH2:19][CH2:18][C@@:17]2([CH3:20])[C:4](=[CH:5][C@H:6]([OH:22])[C@@H:7]3[C@@H:16]2[CH2:15][CH2:14][C@@:12]2([CH3:13])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[OH:21])[CH2:3]1>[Pd]>[OH:1][C@H:2]1[CH2:19][CH2:18][C@@:17]2([CH3:20])[C@@H:4]([CH2:5][C@H:6]([OH:22])[C@@H:7]3[C@@H:16]2[CH2:15][CH2:14][C@@:12]2([CH3:13])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[OH:21])[CH2:3]1

Participants

3

Reactant 1

HCID 98180245-Androstene-3 beta,7 beta,17 beta-triol

Product 1

HCID 68995028Androstane-3,7,17-triol, (3beta,5alpha,7beta,17beta)-

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

AET (I) is reduced by hydrogenation over a palladium on charcoal catalyst to yield 3β,7β,17β-trihydroxy-5α-androstane (CIX)

Sources & evidence

ORD record
ord-270d5a23ffa44d44a1d0b69ffa03ecef
Source dataset
uspto-grants-1995_02
Patent number
US05387583

Reaction notes

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