HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxaspiro[4.5]decan-8-one → 8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | HCID 178418676 | HCID 178418676 | — |
| Product | 8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 15232681 | 88.2% |
Reaction Steps
This compound was prepared from 1,4-cyclohexanedione monoethylene ketal (6.24 g, 40 mmole) and 4-fluorophenyl magnesium bromide (60 mmole) in a manner similar to example 3. The crude product was crystallized from hexane to give the product (8.9 g, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05387593 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-6227bd0c00fd41a4946905d791dbd233 |
| Source note | uspto-grants-1995_02 |