反应详情

A mixture of 4-(2-fluoro-5-methoxybenzyl)pyridine (7.7 g, 35.5 mmole) and platinum oxide (0.7 g) in acetic acid (75 ml) was hydrogenated for 3 hr. The catalyst was removed and the acetic acid removed in vacuo. The residue was dissolved in water and the solution basified with sodium hydroxide. The basic mixture was extracted with ether. The extracts were dried and concentrated in vacuo. The residue was vacuum distilled to give the product (6 g, 75.9%).

1. customThe catalyst was removed
2. customthe acetic acid removed in vacuo
3. dissolutionThe residue was dissolved in water
4. extractionThe basic mixture was extracted with ether
5. customThe extracts were dried
6. concentrationconcentrated in vacuo
7. distillationdistilled