HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2,2-Dimethyl-3-methylene-6-cyano-4-chromanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2,2-Dimethyl-4-oxo-3,4-dihydro-2H-1-benzopyran-6-carbonitrile | HCID 10954598 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,2-Dimethyl-3-methylene-6-cyano-4-chromanone | HCID 14517982 | — |
Reaction Steps
A solution of 24 g of the chromanone, 12 g of paraformaldehyde and 24 ml of piperidine in 300 ml of ethanol is heated at 70° for 3 hours and evaporated. The residue is taken up in dichloromethane/petroleum ether 1:1, the mixture is filtered through silica gel and evaporated, and 2,2-dimethyl-3-methylene-6-cyano-4-chromanone is obtained as an unstable oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05387587 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-5fea985178994710ac11c8eecbb5ec1a |
| Source note | uspto-grants-1995_02 |