HCID 178431214, compound → HCID 178431206, compound

HRID 273753Notes

Reaction equation

HRID 273753 reaction equation
[CH3:1][C:2]1([CH3:24])[CH:11]([OH:12])[CH:10]([O:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([OH:20])[CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:21]([O-])=O)[CH:8]=2)[O:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:24])[CH:11]([OH:12])[CH:10]([O:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([OH:20])[CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:21])[CH:8]=2)[O:3]1

Participants

4

Reactant 1

HCID 178431214HCID 178431214, compound

Product 1

HCID 178431206HCID 178431206, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1 g of 2,2-dimethyl-4-(2-hydroxy-4-pyridyloxy )-6-nitro-3-chromanol in 25 ml of methanol is hydrogenated at 20° and 1 bar on 0.5 g of 5% Pd-C to completion. The mixture is filtered, evaporated and 2,2-dimethyl-4-(2-hydroxy-4-pyridyloxy)-6-amino-3-chromanol is obtained.

Workup

  1. customis hydrogenated at 20°
  2. filtrationThe mixture is filtered
  3. customevaporated

Sources & evidence

ORD record
ord-25dc24c62a804cd29b90ebd024b0bb37
Source dataset
uspto-grants-1995_02
Patent number
US05387587

Reaction notes

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