Dodecanoyl chloride → HCID 178443287, compound

HRID 273758Notes

Reaction equation

HRID 273758 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([SH:9])[NH:8][C:4]=2[CH:3]=1.[C:12](Cl)(=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>N1C=CC=CC=1>[C:12]([NH:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([SH:9])[NH:8][C:4]=2[CH:3]=1)(=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

Participants

4

Reactant 2

HCID 8166Dodecanoyl chlorideHCID 178507340HCID 178507340, compound

Product 1

HCID 178443287HCID 178443287, compoundYield 103.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

5 g of 5-amino-2-mercaptobenzimidazole was dissolved in 50 ml of pyridine and 7.95 g of dodecanoyl chloride was added dropwise thereto under cooling with ice. After stirring, for 3 hours at room temperature, the solution was poured into ice-water. The formed crystals were filtered off and recrystallized from water-containing methanol to obtain 10.9 g of compound (8).

Workup

  1. temperatureunder cooling with ice
  2. filtrationThe formed crystals were filtered off
  3. customrecrystallized from water-
  4. additioncontaining methanol

Sources & evidence

ORD record
ord-9ba35659db014ace80b01f3c39e59bef
Source dataset
uspto-grants-1995_02
Patent number
US05387600

Reaction notes

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