HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetic Acid → 2-Chloromethylbenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetic Acid | HCID 300 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Azane;hydrate | HCID 12896473 | — |
| Product | 2-Chloromethylbenzimidazole | HCID 78571 | 67.9% |
Reaction Steps
To 108 g of o-phenylenediamine, 1 l of 4N hydrochloric acid and 142 g of chloroacetic acid were added and refluxed for 1.5 hours. After allowing to stand overnight, the solution was diluted with 2 l of water and neutralized with dilute ammonia water. The formed crystals were filtered off to obtain 113 g of 2-chlorom ethylbenzimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05387600 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-8aea802ad77c4e789d283f5203dc4688 |
| Source note | uspto-grants-1995_02 |