Triethylamine → HCID 67787118, compound

Participants

Reaction Steps

A solution of 0.53 g (2.26 mmole) of 2-(SR)-phenyl-3-(SR)-hydroxy-(SR)-cyclohexylacetic acid in 35 mL of methanol was treated with 22 mg (0.11 mmole) of p-toluenesulfonic acid monohydrate and the mixture was heated at reflux for 27 hr. The mixture was cooled, treated with 0.02 mL of triethylamine and concentrated in vacuo. The residue was purified by flash chromatography on 67 g of silica eluting with 1.6 L of 8:1 hexanes:ethyl acetate to give 0.506 g (90%) of an oil.

Provenance & Evidence