HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 86748440, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 86748441 | HCID 86748441 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86748440 | HCID 86748440 | 93% |
Reaction Steps
A solution of 56 mg (0.12 mmole) of α-isocyanato-3-(SR)-(3,5-Bis(trifluoromethyl)-benzyloxy)-2-(SR)-phenyl-1-(SR)-methylcyclohexane in 1 mL of methylene chloride was treated with 3 mL of ammonia-saturated methylene chloride at room temperature. After 1 hr, the solution was concentrated in vacuo and the residue purified by flash chromatography on 16 g of silica eluting with 400 mL of 100:2 methylene chloride: methanol to provide 54 mg (93%) of a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05387595 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-31bc6f71d3d14eddb5dfa97b1d971b08 |
| Source note | uspto-grants-1995_02 |