Ethanol → HCID 20093979, compound

HRID 273783Notes

Reaction equation

HRID 273783 reaction equation
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([NH:12][NH2:13])[C:6]2[S:11][CH:10]=[CH:9][C:7]=2[N:8]=1.[CH2:14](O)C>C([O-])([O-])OCC>[Cl:1][CH2:2][C:3]1[N:4]2[CH:14]=[N:13][N:12]=[C:5]2[C:6]2[S:11][CH:10]=[CH:9][C:7]=2[N:8]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 20094178HCID 20094178, compound

Product 1

HCID 20093979HCID 20093979, compound

Reagents, catalysts & solvents 1

HCID 53630039EthylorthoformateSolvent

Conditions

Temperature
125 °C

Procedure

4. 15.7 g of 2-(chloromethyl)-4-hydrazinothieno[3,2-d]pyrimidine are suspended in 280ml of ethyl orthoformate. The suspension is heated (bath temp. 125° C.) while stirring and the ethanol which results is distilled off. After 3 h., the mixture is cooled to 0° C., the precipitate is filtered off and washed with ethanol. The product is dried in a vacuum. There are obtained 15.2 g of 5-(chloromethyl)thieno[2,3-e][1,2,4]triazolo[4,3-c]-pyrimidine. m.p. above 400° C. (dec.).

Workup

  1. distillationis distilled off
  2. temperaturethe mixture is cooled to 0° C.
  3. filtrationthe precipitate is filtered off
  4. washwashed with ethanol
  5. customThe product is dried in a vacuum

Sources & evidence

ORD record
ord-9fad027ca04f4e48a3bdb6c8122eedd6
Source dataset
uspto-grants-1995_02
Patent number
US05387585

Reaction notes

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