Ammonia → HCID 20094140, compound

Participants

Reaction Steps

6. 13 g of 5,10-dimethylimidazo[1,2-c]quinazoline in 350 ml of 6N hydrochloric acid are stirred at 95° C. and then cooled in an ice bath. The reaction solution is poured into 30 ml of 25% ammonia and stirred in an ice bath for 10 min. The crystals are filtered off, washed with water and dried in a vacuum. 10.1 g of 3-methyl-2-(1H-2-imidazolyl)aniline are obtained. The filtrate is extracted three times with chloroform. The extracts are evaporated in a vacuum. A further 1.4 g of 3-methyl-2-(1H-2-imidazolyl) aniline are obtained. The m.p. lies at 174°-175° C. after recrystallization from ethyl acetate.

Provenance & Evidence