HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Bis(methylthio)-2-nitroethylene → 1-Nitro-2-(2-propynylamino)-2-{2-[(4-hydroxymethyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Bis(methylthio)-2-nitroethylene | HCID 83623 | — |
| Reactant | Propargylamine | HCID 239041 | — |
| Reactant | 2-[(5-Hydroxymethyl-1H-imidazol-4-yl)methylthio]ethylamine | HCID 12951530 | — |
| Reactant | 1-nitro-2-methylthio-2-{2-[(4-hydroxymethyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene | HCID 70589405 | — |
| Product | 1-Nitro-2-(2-propynylamino)-2-{2-[(4-hydroxymethyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene | HCID 74042596 | — |
Reaction Steps
When 2-[(4-hydroxymethyl-1H-imidazol-5-yl)methylthio]-ethylamine [prepared according to the procedure described in Belgian Pat. No. 843,840] is reacted with 1,1-bis(methylthio)-2-nitroethylene according to the procedure of Example 6, Step A, and the resultant 1-nitro-2-methylthio-2-{2-[(4-hydroxymethyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene is treated with propargylamine by the procedure of Example 6, Step B, the title compound is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04221737 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-561d46c7b5e4437a9b421a6accee19cf |
| Source note | uspto-grants-1980_09 |