反应详情

温度

80 °C

504 g (3 mol) of 2-amino-4-nitro-1-methoxybenzene are introduced into 860 ml of acetic acid and 600 ml of water (or the combined main filtrate and first wash filtrate of a previous batch) and the mixture is heated to 80° C. 358 g (3.2 mol) of acetic anhydride are added dropwise in the course of 10 minutes. The mixture is subsequently stirred at 80° C. for 4 hours, and then cooled to room temperature, while stirring, by removing the heating bath and finally to 15° C. The pale yellow needles which have precipitated are filtered off with suction, washed with 300 ml of 60% strength acetic acid and 1500 ml of water in several portions and dried.

1. temperaturecooled to room temperature
2. stirringwhile stirring
3. customby removing the heating bath
4. customfinally to 15° C
5. customThe pale yellow needles which have precipitated
6. filtrationare filtered off with suction
7. washwashed with 300 ml of 60% strength acetic acid and 1500 ml of water in several portions
8. customdried