反应详情

2-Trimethylsilyl-4-furaldehyde (1.57 g, 9.35 mmol) was added to a suspension of sodium borohydride (424 mg, 11.2 mmol) in methanol (10 ml) at 0° C. After 45 minutes, most of the methanol was evaporated and the residue taken up in ethyl ether. The ethyl ether extracts were combined, washed (water), dried (magnesium sulfate) and evaporated to dryness to give an oil, which was purified by flash chromatography on silica using 30% ethyl ether/hexane to give the title alcohol as a pale yellow oil.

1. custommost of the methanol was evaporated
2. washwashed (water)
3. dry with materialdried (magnesium sulfate)
4. customevaporated to dryness
5. customto give an oil, which
6. customwas purified by flash chromatography on silica using 30% ethyl ether/hexane