反应详情

Sodium borohydride (353 mg, 0.93 mmol) was added portionwise to a solution of 2-triethylsilyl-4-furaldehyde (1.64 g, 7.79 mmol) in methanol (10 ml) at 0°. After 1 hour, most of the methanol was evaporated and the residue dissolved in a minimum amount of dilute hydrochloric acid. Extraction (ethyl acetate), drying (magnesium sulfate) and evaporation gave an oil, which was purified by flash chromatography on silica using 20% ethyl ether/hexane. Fractions with Rf of about 0.07 (10% ethyl ether/hexane) gave after evaporation the title alcohol as a colorless oil.

1. custommost of the methanol was evaporated
2. dissolutionthe residue dissolved in a minimum amount of dilute hydrochloric acid
3. extractionExtraction (ethyl acetate)
4. customdrying
5. custom(magnesium sulfate) and evaporation
6. customgave an oil, which
7. customwas purified by flash chromatography on silica using 20% ethyl ether/hexane
8. customFractions with Rf of about 0.07 (10% ethyl ether/hexane) gave
9. customafter evaporation the title alcohol as a colorless oil