HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6,7,8-Tetrahydro-1,3-dioxolo(4,5-g)isoquinoline → 6-[6-(3,4-Dimethoxyphenyl)-6-[(4-methylphenyl)thio]-hexyl]-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6,7,8-Tetrahydro-1,3-dioxolo(4,5-g)isoquinoline | HCID 27013 | — |
| Reactant | 4-[6-Bromo-1-[(4-methylphenyl)thio]hexyl]-1,2-dimethoxybenzene | HCID 10812203 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-[6-(3,4-Dimethoxyphenyl)-6-[(4-methylphenyl)thio]-hexyl]-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline | HCID 10577864 | 91.7% |
Reaction Steps
The procedure of Example 46 is repeated using 3.67 g of 4-[6-bromo-1-[(4-methylphenyl)thio]hexyl]-1,2-dimethoxybenzene in 40 mL of acetonitrile and 2.65 g of 6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline. This affords 4.13 g of the desired product as a yellow gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05387685 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-d93e45c107a449178016385610384b81 |
| Source note | uspto-grants-1995_02 |