4-Methylbenzenethiol → HCID 10603282, compound

HRID 274010Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11](O)([CH2:32][CH3:33])[CH2:12][CH2:13][CH2:14][CH2:15][C:16]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][C:22]([O:30][CH3:31])=[C:23]([O:28][CH3:29])[CH:24]=3)[CH2:19]2)=[O:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:35][C:36]1[CH:41]=[CH:40][C:39]([SH:42])=[CH:38][CH:37]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([S:42][C:39]2[CH:40]=[CH:41][C:36]([CH3:35])=[CH:37][CH:38]=2)([CH2:32][CH3:33])[CH2:12][CH2:13][CH2:14][CH2:15][C:16]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][C:22]([O:30][CH3:31])=[C:23]([O:28][CH3:29])[CH:24]=3)[CH2:19]2)=[O:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

Reactant 2

HCID 78114-Methylbenzenethiol

HCID 10552360HCID 10552360, compound

Product 1

HCID 10603282HCID 10603282, compoundYield 58%

Procedure

The procedure of Example 60 is repeated using of 2.7 g of 2-[6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline and 1.06 g of p-thiocresol. This affords 1.92 g of the desired product as a white foam.

Sources & evidence

ORD record: ord-2ddfb89e67074dd48eba420d6e5ebdf1
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05387685

Reaction notes

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