反应详情

An aqueous solution (92 ml) of sodium borohydride (18.29 g) was added dropwise to a stirred solution of 7-benzylamino-3-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one (25.01 g) at ambient temperature over 20 minutes. The resulting mixture was stirred for 4 hours and allowed to stand overnight at the same temperature and evaporated in vacuo. The residue was diluted with water and extracted twice with dichloromethane. The combined extracts were washed with brine, dried over sodium sulfate, treated with 4N hydrogen chloride in ethyl acetate, and evaporated in vacuo. The residue was suspended in methanol and filtered. The filtrate was evaporated in vacuo, diluted with ammonia aqueous solution, and extracted twice with dichloromethane. The combined extracts were washed with brine, dried over sodium sulfate, and chromatographed over silica gel using dichloromethane-methanol. The eluate was evaporated in vacuo and the residue was washed with diethyl ether to afford 7-benzylamino-3-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (7.33 g) as a dark yellow powder (diastereomers mixture).

1. waitto stand overnight at the same temperature
2. customevaporated in vacuo
3. additionThe residue was diluted with water
4. extractionextracted twice with dichloromethane
5. washThe combined extracts were washed with brine
6. dry with materialdried over sodium sulfate
7. additiontreated with 4N hydrogen chloride in ethyl acetate
8. customevaporated in vacuo
9. filtrationfiltered
10. customThe filtrate was evaporated in vacuo
11. additiondiluted with ammonia aqueous solution
12. extractionextracted twice with dichloromethane
13. washThe combined extracts were washed with brine
14. dry with materialdried over sodium sulfate
15. customchromatographed over silica gel
16. customThe eluate was evaporated in vacuo
17. washthe residue was washed with diethyl ether