Ammonia → alpha-(2-Hydroxyethyl)-2-oxo-1-pyrrolidineacetamide

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Reaction Steps

10.15 g (0.06 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are dissolved in 100 ml of methanol and the solution is saturated with ammonia, the temperature rising spontaneously to 40° C. The mixture is kept at that temperature for 30 minutes, whereupon it is allowed to return to ambient temperature. The reaction mixture is then evaporated under reduced pressure and the resulting powder is recrystallized from absolute ethanol. 10 g of alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide are obtained. M.P.: 164°-165° C.; yield: 90% of theory.

Provenance & Evidence