Butylamine → N-n-butyl-alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide

Participants

Reaction Conditions

Reaction Steps

10.14 g (0.06 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are dissolved in 50 ml of methanol and 8.78 g (0.12 mol) of n-butylamine are added to the solution. The reaction mixture is heated under reflux (65° C.) for 3 hours and then evaporated under a high vacuum. 12.3 g (yield: 85% of theory) of N-n-butyl-alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide are obtained in the form of a syrup.

Provenance & Evidence