HCID 178509655, compound → HCID 178509654, compound

Participants

Reaction Steps

A solution of 9 g of the compounds prepared in Example 43 in 360 ml of acetic acid is reduced by catalytic hydrogenation in the presence of 1.8 g of 5% palladium-on-charcoal. The reaction is carried out at atmospheric pressure and at 50° C. The catalyst is filtered off on Celite 545 and washed with acetic acid and the filtrate is concentrated and then purified by chromatography on silica gel (eluent: chloroform 95%/methanol 5%) to give 4.5 g of the starting material and 2.2 g of 6-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-hydroxymethyl-1,2,4-triazolo[1,5-a]pyrimidine.

Provenance & Evidence