Ethanol → HCID 73504073, compound

HRID 274111Notes

Reaction equation

HRID 274111 reaction equation
[OH:1][N:2]=[C:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=[O:17])=[CH:11][CH:10]=1.[CH2:19](O)[CH3:20]>OS(O)(=O)=O.C1(C)C=CC=CC=1>[OH:1][N:2]=[C:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 702EthanolHCID 73504072HCID 73504072, compound

Product 1

HCID 73504073HCID 73504073, compound

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 1140TolueneSolvent

Procedure

Another method is also possible: a mixture of 5.8 g of 4-[(2-hydroxyiminocylcopentyl)methyl]-benzeneacetic acid, 4.1 ml of ethanol 98° and 2 drops of concentrated H2SO4 in 20 ml of toluene is refluxed for 6 hours, in a reactor above which there is a Dean-Stark separator. After cooling, the toluene is washed with a solution of NaHCO3, then with H2O. The organic phase is dried over Na2SO4 and is concentrated. The product obtained is in the form of a yellow oil.

Workup

  1. temperatureis refluxed for 6 hours, in a reactor above which there
  2. temperatureAfter cooling
  3. washthe toluene is washed with a solution of NaHCO3
  4. dry with materialThe organic phase is dried over Na2SO4
  5. concentrationis concentrated
  6. customThe product obtained

Sources & evidence

ORD record
ord-3204e5b89511474f8bb738e89f8499df
Source dataset
uspto-grants-1995_02
Patent number
US05387709

Reaction notes

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