HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl N-(2-chloroacetyl)carbamate → 6-(Methylthio)imidazo[1,2-a]pyridine-2-carbamic acid, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl N-(2-chloroacetyl)carbamate | HCID 518783 | — |
| Reactant | 5-(Methylsulfanyl)pyridin-2-amine | HCID 15179797 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | 6-(Methylthio)imidazo[1,2-a]pyridine-2-carbamic acid, methyl ester | HCID 86737200 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A suspension of 2-amino-5-(methylthio)pyridine (0.667 mol) and methyl(chloroacetyl)carbamate (0.667 mol) in 325 ml of HMPT is heated at 100° C. for 5 hours. After dilution with 2000 ml of H2O, the product is collected by filtration, successively washed with H2O, MeOH and CH2Cl2, and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04221796 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-c727c9887d654ab193b8d135c22c6424 |
| Source note | uspto-grants-1980_09 |