1,3-Dimethyl-2-imidazolidinone → 1-[[2-(2-Hydroxyethyl)phenyl]methyl]cyclopentanecarbonitrile

Participants

Reaction Steps

Obtained by operating as in example 87a, from 7.8 g (77 mmoles) of diisopropylamine, 48.2 ml of a 1.6M solution of n-butyllithium in hexane, 6.7 g (70 mmoles) of commercial cyclopentanecarbonitrile, 18 ml of 1,3-dimethylimidazolidin-2-one and 20.5 g (71.4 mmoles) of the compound prepared in example 92c in 20 ml of tetrahydrofuran. After distillation, there is obtained 8.8 g (yield=55.0%) of a beige viscous liquid. b.p.0.4 =165 ° C.

Provenance & Evidence