Sodium Hydroxide → HCID 86748447, compound

Participants

Reaction Steps

Ethanol (5.5 ml) and 1N aqueous sodium hydroxide (1.38 ml) were added to methyl 2-butyl-4-chloro-1-[3-bromo-2-(2-ethoxycarbonylphenyl)-2H-indazol-5-yl]methyl-1H-imidazole-5-carboxylate (0.132 g, 0.230 mmol) as obtained in Example 8, and the mixture was stirred at room temperature for one day. The mixture was concentrated in an evaporator, and ion-exchanged water (5 ml) was added thereto, followed by stirring. Conc. hydrochloric acid was dropwise added thereto to adjust its pH to 5-6. The resultant solid was filtered off and washed three times with ion-exchanged water (2.5 ml). Two equivalent amounts of N/10 aqueous sodium hydroxide was added to dissolve the solid obtained by drying in vacuo at 37° C. for two days. Lyophilization of the solution afforded 0.104 g of disodium 1-[3-bromo-2-(2-carboxyphenyl)-2H-indazol-5-yl]methyl-2-butyl-4-chloro-1H-imidazole-5-carboxylate.

Provenance & Evidence