Benzene, 1-bromo-4-(trifluoromethyl)- → HCID 178495104, compound

HRID 274148Notes

Reaction equation

HRID 274148 reaction equation
[CH3:1][O:2][CH:3]=[CH:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH2:7][CH2:6]1.BrC1C=CC(C(F)(F)F)=CC=1>>[CH3:1][O:2][CH2:3][CH2:4][C@H:5]1[CH2:6][CH2:7][C@H:8]([C:11]2[CH:12]=[CH:13][C:14]([C:17]([F:18])([F:20])[F:19])=[CH:15][CH:16]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 178495103HCID 178495103, compound

Product 1

HCID 178495104HCID 178495104, compound

Procedure

Hydrogenation of 1-methoxy-2-[trans-4-[p-trifluoromethylphenyl)cyclohexyl]ethene [obtainable from p-bromotrifluorotoluene by the above synthesis scheme] on Pd/C and customary work-up give trans-4-methoxyethyl-(p-trifluoromethylphenyl)cyclohexane.

Sources & evidence

ORD record
ord-e7e7461cfa2a4d56ab00ea06b7170e1b
Source dataset
uspto-grants-1995_02
Patent number
US05389295

Reaction notes

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