HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178444306, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetophenone | HCID 7410 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 1-(Difluoromethoxy)-4-iodobenzene | HCID 2737008 | — |
| Reactant | HCID 178436318 | HCID 178436318 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 178444306 | HCID 178444306 | — |
Reaction Steps
A solution of 15.3 g of 4-(trans-4-pentylcyclohexyl)phenylacetylene (available from the acetophenone by dehydration, using PCl5 /KOT), 16.2 g of difluoromethoxy-4-iodobenzene, 100 ml of triethylamine, 0.085 g of bis(triphenylphosphine)dichloropalladium and 0.11 g of copper(I) iodide is stirred at room temperature for 3 hours. The cloudy mixture is stirred into dilute hydrochloric acid (500 ml of water +200 ml of 37% hydrochloric acid), extracted with t-butyl methyl ether and worked up as usual. m.p.: 62° C., c.p.: 203.1° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05389292 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-d747d02d422b4ca18740343545cc522e |
| Source note | uspto-grants-1995_02 |