反应详情

温度

40 °C

6.4 ml of thionyl chloride are added dropwise to a suspension of 15.06 g of N-methylarginine in 50 ml of absolute methanol at -10° C. The mixture is then allowed to come to room temperature, while stirring. Since starting material is still present after a reaction time of 17 hours, a further 9.6 ml of thionyl chloride are added in portions, the mixture is heated at 40° C. for 4 hours, the insoluble material is filtered off with suction and the filtrate is concentrated. The oily residue is dissolved in water, the insoluble material is filtered off and the product is freeze-dried.

1. customto come to room temperature
2. customafter a reaction time of 17 hours
3. filtrationthe insoluble material is filtered off with suction
4. concentrationthe filtrate is concentrated
5. dissolutionThe oily residue is dissolved in water
6. filtrationthe insoluble material is filtered off
7. customthe product is freeze-dried