HCID 86748453, compound → HCID 86748452, compound

HRID 274221Notes

Reaction equation

HRID 274221 reaction equation
[N+:1]([C:4]1[CH:36]=[CH:35][C:7]([CH2:8][C@@H:9]2[NH:13][C:12](=[O:14])[N:11]([N:15]([C:31](=[O:33])[CH3:32])[C@H:16]([C:21]([NH:23][C@H:24]([C:28]([OH:30])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH2:17][C:18](=[O:20])[OH:19])[C:10]2=[O:34])=[CH:6][CH:5]=1)([O-])=O>CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C@@H:9]2[NH:13][C:12](=[O:14])[N:11]([N:15]([C:31](=[O:33])[CH3:32])[C@H:16]([C:21]([NH:23][C@H:24]([C:28]([OH:30])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH2:17][C:18](=[O:19])[OH:20])[C:10]2=[O:34])=[CH:35][CH:36]=1

Participants

3

Reactant 1

HCID 86748453HCID 86748453, compound

Product 1

HCID 86748452HCID 86748452, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

220 mg (0.43 mmol) of (5-(S)-(4-nitrobenzyl)-2,4-dioxoimidazolidin-3-yl)-acetyl-L-aspartyl-L-valine are dissolved in 50 ml of methanol. After addition of 10 mg of 10% strength Pd-on-charcoal, the mixture is hydrogenated at room temperature for 3 hours, the catalyst is filtered off, the filtrate is concentrated and the product is freeze-dried.

Workup

  1. filtrationthe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe product is freeze-dried

Sources & evidence

ORD record
ord-d5c6f547567f4941abfabefc44dad639
Source dataset
uspto-grants-1995_02
Patent number
US05389614

Reaction notes

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