3-Fluorophenol → HCID 67783450, compound

HRID 274257Notes

Reaction equation

[OH:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[CH:26]([NH:27][C:28](=[O:37])[CH2:29][O:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25](=[O:38])[N:7]2[C:8]=1[C:9]([O:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10].[F:39][C:40]1[CH:41]=[C:42](O)[CH:43]=[CH:44][CH:45]=1>>[F:39][C:40]1[CH:45]=[C:44]([CH:43]=[CH:42][CH:41]=1)[O:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[CH:26]([NH:27][C:28](=[O:37])[CH2:29][O:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25](=[O:38])[N:7]2[C:8]=1[C:9]([O:11][CH:12]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:10]

Participants

Reactant 2

HCID 97433-Fluorophenol

HCID 67783388HCID 67783388, compound

Product 1

HCID 67783450HCID 67783450, compound

Procedure

The procedure described in Example 1(a) was repeated, but using 2.00 g of diphenylmethyl 3-hydroxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylate and m-fluorophenol, to afford 357 mg of the title compound as a powder.

Sources & evidence

ORD record: ord-03e524a8d8ee4612a389f1e8ed4c0ec5
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05389626

Reaction notes

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