3,4-Difluorophenol → HCID 67783391, compound

HRID 274263Notes

Reaction equation

HRID 274263 reaction equation
[O:1]([CH2:8][C:9]([NH:11][CH:12]1[C:37](=[O:38])[N:14]2[C:15]([C:21]([O:23][CH:24]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:22])=[C:16]([CH2:19][OH:20])[CH2:17][S:18][C@H:13]12)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:39][C:40]1[CH:41]=[C:42](O)[CH:43]=[CH:44][C:45]=1[F:46]>>[F:39][C:40]1[CH:41]=[C:42]([CH:43]=[CH:44][C:45]=1[F:46])[O:20][CH2:19][C:16]1[CH2:17][S:18][C@@H:13]2[CH:12]([NH:11][C:9](=[O:10])[CH2:8][O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:37](=[O:38])[N:14]2[C:15]=1[C:21]([O:23][CH:24]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:22]

Participants

3

Reactant 2

HCID 759273,4-DifluorophenolHCID 67783388HCID 67783388, compound

Product 1

HCID 67783391HCID 67783391, compound

Procedure

The procedure described in Example 1(a) was repeated, but using 2.00 g of diphenylmethyl 7-phenoxyacetamido-3-hydroxymethyl-3-cephem-4-carboxylate and 3,4-difluorophenol, to afford 326 mg of the title compound as a powder.

Sources & evidence

ORD record
ord-b53b3eef256f48a3a8239ea419854678
Source dataset
uspto-grants-1995_02
Patent number
US05389626

Reaction notes

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