HCID 10489281, compound → HCID 10773751, compound

HRID 274296Notes

Reaction equation

HRID 274296 reaction equation
C([O:4][CH2:5][CH:6]([CH:12]([CH3:14])[CH3:13])[CH2:7][S:8]([NH2:11])(=[O:10])=[O:9])(=O)C.C[O-].[Na+]>CO>[OH:4][CH2:5][CH:6]([CH:12]([CH3:14])[CH3:13])[CH2:7][S:8]([NH2:11])(=[O:9])=[O:10]

Participants

4

Reactant 2

HCID 10489281HCID 10489281, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 10773751HCID 10773751, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 50 ml of methanol was dissolved 7.0 g of 3-acetoxy-2-isopropyl-1-propanesulfonamide and while the solution was stirred at room temperature, 6.5 g of 28 w/w % sodium methoxide was added and reacted for 30 minutes. The reaction mixture was then concentrated to dryness. The residue was subjected to silica gel (100 g) column chromatography and elution was carried out with chloroform-methanol (9:1) to provide 4.4 g of the title compound. m.p. 83°-84° C.

Workup

  1. customreacted for 30 minutes
  2. concentrationThe reaction mixture was then concentrated to dryness
  3. washThe residue was subjected to silica gel (100 g) column chromatography and elution

Sources & evidence

ORD record
ord-bd0cb60e7708439883fd7927a01bf8b3
Source dataset
uspto-grants-1995_02
Patent number
US05389633

Reaction notes

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