反应详情

Add (drop by drop while stirring at -10° ) 10 g of 2-benzylperhydroazepine to 43 ml of concentrated sulfuric acid. Then, at the same temperature, add 33 ml of concentrated nitric acid to the thus-prepared reaction mixture and allow it to heat slowly to room temperature. Stir it for a further hour. Pour the resulting admixture into 500 g of ice, alkalize it with 6 N caustic soda solution and then extract it with diethyl ether. Dry the organic phase over sodium sulfate and distil off the solvent from the dried organic phase to obtain 12.0 g (97% of theory) of the title compound as a red oil.

1. customto the thus-prepared reaction mixture
2. extractionextract it with diethyl ether
3. dry with materialDry the organic phase over sodium sulfate
4. customdistil off the solvent from the dried organic phase