HCID 178441737, compound → 1H-Imidazole-4-carboxaldehyde, 5-bromo-2-butyl-

HRID 274338Notes

Reaction equation

HRID 274338 reaction equation
[Br:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH2:9][CH3:10])=[N:4][C:3]=1[CH2:11][OH:12]>[O-2].[O-2].[Mn+4].O1CCOCC1>[Br:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH2:9][CH3:10])=[N:4][C:3]=1[CH:11]=[O:12]

Participants

4

Reactant 1

HCID 178441737HCID 178441737, compound

Product 1

HCID 100141011H-Imidazole-4-carboxaldehyde, 5-bromo-2-butyl-Yield 85.9%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

4.37 g of the product of Step A were introduced into 130 ml of dioxane and then 16.32 g of manganese dioxide were added with stirring. The mixture was heated to approximately 100° C. for about 2 hours, then filtered. The filtrate was rinsed with dioxane and evaporated to obtain 3.72 g of the expected product melting at 113° C.

Workup

  1. filtrationfiltered
  2. washThe filtrate was rinsed with dioxane
  3. customevaporated

Sources & evidence

ORD record
ord-1d42b7e726394a0e835e15a83ec43476
Source dataset
uspto-grants-1995_02
Patent number
US05389634

Reaction notes

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